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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Drug Discov Today Dis Models. 2011 Spring;8(1):37–46. doi: 10.1016/j.ddmod.2011.05.002

Figure 1.

Figure 1

Digital fluorescent micrographs of in-vivo protease activity as detected with microzymography using a quenched fluorogenic peptide substrate for MMP (MMP-1 and -9) activity in mesenteric microcirculation of WKY and SHR before and after chronic MMP inhibition (with doxycycline) (43). Note the enhanced fluorescent emission over the endothelial cells in the SHR arterioles (A), capillaries (C), and venules (V).