Figure 2.

Comparison of the disease phenotype of MOG-induced, active EAE in wild-type and β₂-integrin-deficient mice. Representative disease curves for wild-type (WT), CD11a^−/−, CD11b^−/−, CD11c^−/−, and CD11d^−/− mice with active EAE over the course of 30 days are shown. Onset and progression of EAE symptoms were monitored using a clinical scale as follows: 0, asymptomatic; 1, loss of tail tone; 2, flaccid tail; 3, incomplete paralysis of one or two hind limbs; 4, complete hind-limb paralysis; 5, moribund. CD11a^−/− and CD11b^−/− mice have delayed disease onset and the least severe disease phenotype. CD11c^−/− mice have an intermediate disease phenotype, and CD11d^−/− mice present with disease identical to wild-type mice. (Adapted from refs. [12, 41, 42, 44].)