Table 1.
Drug | tmax(h) | Bioavailability (%) | t½ (h) | Vd (L) | Interaction with food | Elimination (feces/urine) |
---|---|---|---|---|---|---|
Losartan | 1 (3–4)* | 33 | 2 (4–6)* | 34 (12)* | No | 60/35 |
Valsartan | 2 | 23 | 7 | 17 | No | 83/13 |
Irbesartan | 1–2 | 60–80 | 12–20 | 53–93 | No | 80/20 |
Candesartan | 3–5 | 42 | 9–13 | 0.13 L/kg | No | 67/33 |
Eprosartan | 2–6 | 13 | 5–7 | 308 | No | 90/10 |
Telmisartan | 1 | 43 | 24 | 500 | No | >98% fecal |
Olmesartan | 1.4–2.8 | 26† | 11.8–14.7 | 14.7–19.7 | No | 35%–49% urinary recovery rate‡ |
Azilsartan | 1.5–3 | 60 | 11 | 16 | No | 55/42 |
Notes:
Values in parentheses are for EXP 3174, the active metabolite of losartan;
olmesartan medoxomil;
intravenous olmesartan.
Abbreviations: PK, pharmacokinetic; ARB, angiotensin II receptor blocker; t½, terminal elimination half-life; tmax, time to maximum plasma concentration; Vd, volume of distribution.