Table 1.

Comparative pharmacokinetic properties of angiotensin II receptor blockers⁴³,¹²⁸

Drug	tmax(h)	Bioavailability (%)	t½ (h)	Vd (L)	Interaction with food	Elimination (feces/urine)
Losartan	1 (3–4)*	33	2 (4–6)*	34 (12)*	No	60/35
Valsartan	2	23	7	17	No	83/13
Irbesartan	1–2	60–80	12–20	53–93	No	80/20
Candesartan	3–5	42	9–13	0.13 L/kg	No	67/33
Eprosartan	2–6	13	5–7	308	No	90/10
Telmisartan	1	43	24	500	No	>98% fecal
Olmesartan	1.4–2.8	26†	11.8–14.7	14.7–19.7	No	35%–49% urinary recovery rate‡
Azilsartan	1.5–3	60	11	16	No	55/42

Notes:

^*Values in parentheses are for EXP 3174, the active metabolite of losartan;

^†olmesartan medoxomil;

^‡intravenous olmesartan.

Abbreviations: PK, pharmacokinetic; ARB, angiotensin II receptor blocker; t_½, terminal elimination half-life; t_max, time to maximum plasma concentration; V_d, volume of distribution.