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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: J Med Chem. 2011 May 19;54(12):4147–4159. doi: 10.1021/jm2002348

Figure 6. Activation of Nrf2 genes by compound 2b is independent of ROS generation.

Figure 6

Human bronchial epithelial cells (Beas-2B) were treated with compound 2b (10 µM) in the presence of an antioxidant, N-acetyl cystiene (10 mM, NAC). Cells were harvested 24 h after the treatment, and the Nrf2-driven expression of NQO1, HO-1, and GCLM was quantified. β-actin was used for normalization. Data are representative of 3 independent experiments. Values shown are mean ± SD of triplicate wells (P ≤ 0.05).