Table 2.
List of positive leads from primary screening and their effect on cell viability
| Entry | Compound | Relative Fold Changea | % Cell Viability |
|
|---|---|---|---|---|
| GCLM | NQO1 | |||
| 1 | DMSO | 1 | 1 | 100 |
| 2 | sulforaphane | 2.7 | 3.6 | 97.3 |
| 3 | 2a | 5 | 5.3 | 144.8 |
| 4 | 2b | 4.5 | 4.6 | 100.9 |
| 5 | 2c | 5.6 | 4.3 | 96.6 |
| 6 | 2d | 5.4 | 4.6 | 96 |
| 7 | 2e | 5.4 | 4.5 | 105 |
| 8 | 2f | 5.7 | 5.3 | 101.1 |
| 9 | 2i | 4 | 3.7 | 87.1 |
| 10 | 2k | 5.4 | 4.1 | 101.6 |
| 11 | 2l | 4.4 | 4.3 | 145.3 |
| 12 | 3c | 4.6 | 3.5 | 95.3 |
| 13 | 3i | 3.8 | 3.9 | 108.2 |
| 14 | 4b | 4.3 | 5.4 | 91 |
| 15 | 4d | 3.5 | 4.6 | 104.1 |
| 16 | 4e | 5 | 4.8 | 92.6 |
| 17 | 4g | 4.1 | 4 | 91.6 |
| 18 | 4j | 4.1 | 3.7 | 100.1 |
| 19 | 5d | 4.6 | 4.3 | 93.2 |
| 20 | 5f | 4.1 | 3.7 | 75.8 |
| 21 | 5i | 3.4 | 4.1 | 90.9 |
a
Data presented are representative of 3 independent experiments.
Values shown are mean ± SD of quadruplicate wells.