Figure 5. Versican G3 domain enhanced breast cancer cell apoptosis induced by Docetaxel, while cell apoptosis was reduced when treated with Doxorubicin, or Epirubicin.
a) G3-transfected and vector-transfected 4T07 cells (1×105) were inoculated in 12 well culture dishes. After cultured for 12 hours, all samples were treated with 2 µM Docetaxel, 8 µM Doxorubicin, 10 µM Epirubicin, 15 mM Cyclophosphamide, or 30 µM Trastuzumab for 24 hours. Cell viability was observed by light microscopy. b) After treated with 2 µM Docetaxel, 8 µM Doxorubicin, or 10 µM Epirubicin for 2 hours, all the samples were subjected to Annexin V assays.