Table 6. Additive effects of SNP1 and SNP4 genotypes.^* .

SNP1 genotype & SNP4 genotype	N case	N control	OR (95% CI)	P
AA & C_§	362	535	Ref	ref
AA & GG	439	469	1.37 (1.24–1.51)	0.001
AG & C_	436	461	1.42 (1.28–1.56)	4×10−4
AG & GG	959	865	1.61 (1.48–1.76)	2×10−8
GG & C_	47	38	1.78 (1.41–2.26)	0.01
GG & GG	531	414	1.94 (1.76–2.14)	2×10−11

*NGRC and replication are pooled.

^§The C allele of SNP4 is rare; therefore we combined CC and CG genotypes and denoted as C_.

N = number of individuals with each genotype combination. Risk alleles are shown in bold. Tests were adjusted for age and sex.