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. 2011 Nov 9;6(11):e27579. doi: 10.1371/journal.pone.0027579

Figure 7. Reduced correlations of expression profiles for genes in the same pathways.

Figure 7

For each of the 186 KEGG pathways, the average Spearman correlation coefficient was calculated across all pairs of genes in the pathway. (A) Distributions of the average correlations of the 186 pathways. (B) Average correlations of the 186 pathways in normal tissues and NCI-60 cell lines. Note most of the pathways show stronger gene co-expression in normal tissues than in cancer cell lines.