Table 1. Comparison of staining for markers in MEC of mice of different ages and with different mucopolysaccharide storage diseases.
MPS | IIIB | IIIB | IIIB | IIIB | IIIA | IIIA | I | I | II | VI |
Age (mo) | 0.5 | 1 | 3 | 6 | 4 | 7 | 6 | 12 | 7 | 12 |
Glypican 1 | - | + | ++ | ++ | ++ | ++ | + | + | + | - |
SCMAS | - | + | ++ | ++ | ++ | ++ | + | ++ | + | - |
LC3 | - | + | ++ | ++ | ++ | ++ | - | +/− | +/− | - |
Nitroty | - | + | ++ | ++ | ++ | ++ | - | +/− | +/− | - |
O-GlcNAc | - | + | ++ | ++ | + | nd | + | + | - |
Staining: ++ intense to moderate.
+ weak.
+/- a few positive cells.
− not detected.
nd not determined.