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. 1999 Feb;119(2):497–506. doi: 10.1104/pp.119.2.497

Figure 2.

Figure 2

Phylogenetic relationship of 27 PRPP synthase polypeptides from 16 different organisms. The unrooted tree was constructed as described in Methods. Numbers indicate isoforms of PRPP synthase. Asterisks indicate enzymes that have been shown experimentally to catalyze PRPP formation in vitro. A. thaliana 1 (accession no. X83764), A. thaliana 2 (accession no. X92974), B. caldolyticus (Krath and Hove-Jensen, 1996; accession no. X83708), B. subtilis (Nilsson et al., 1989; accession no. X16518), E. coli (Hove-Jensen et al., 1986; accession no. M13174), G. intestinalis (Kyradji and Bagnara, 1998; accession no. AF042173), H. influenzae (Fleischman et al., 1995; accession no. U32834), Human 1 (Roessler et al., 1990; accession no. D00860), Human 2 (Iizasa et al., 1989; accession no. Y00971), Human 3 (Taira et al., 1990; accession no. M57423), L. donovani (Hendrickson et al., 1993; accession no. M76553), Listeria monocytogenes (Gouin et al., 1994; accession no. M92842), M. jannaschii (Bult et al., 1996; J.N. McGuire, personal communication; accession no. U67576), P. falciparum (accession no. U54642), Pyrococcus sp. (Naeem et al., 1997; accession no. D79364), Rat 2 (Taira et al., 1987; accession no. M17259), S. cerevisiae 1 (Carter et al., 1994; accession no. X70069), S. cerevisiae 2 (Carter et al., 1994; accession no. X74414), S. cerevisiae 3 (Carter et al., 1994; accession no. X74415), S. cerevisiae 4 (Carter et al., 1994; accession no. Z35829), S. cerevisiae 5 (Hernando et al., 1998; accession no. X91067), Synechococcus sp. (Nagaya et al., 1993; accession no. D14994), and Synechocystis sp. (accession no. D64004).