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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Biotechnol. 2011 Oct 9;29(11):1005–1010. doi: 10.1038/nbt.1989

Fig. 4. Treatment with siCCR2 reduces inflammation in atherosclerotic lesions in apoE-/- mice.

Fig. 4

(a) FACS analysis of cell suspensions retrieved from aortas after 3 weeks of treatment with siRNA targeting CCR2 (siCCR2) or control siRNA treatment (siCON). (b) Number of monocytes and macrophages (Mo/MΦ) and Ly-6Chigh monocytes in the aortas of apoE-/- mice (n = 10 per group). (c) Immunohistochemical analysis of aortic roots for CD11b and lesion size (n = 8-14 per group). ROI: region of interest. AU: arbitrary units. Mean ± SD, * P < 0.05.