Table 1.

ED₅₀ values and dose ratios for quinpirole-induced yawning.

Group 1
Standard Chow		High Fat Chow		Ratio (Standard/High Fat)
Ascending	Descending	Ascending	Descending	Ascending	Descending
0.025a	0.148	0.007	0.060	3.7	2.5
0.022, 0.029b	0.136, 0.161	0.006, 0.008	0.057, 0.063

Group 2
High Fat Chow		Standard Chow		Ratio (High Fat/Standard)
Ascending	Descending	Ascending	Descending	Ascending	Descending
0.006	0.070	0.006	0.052	1.0	1.3
0.005, 0.007	0.065, 0.074	0.005, 0.006	0.045, 0.061

	Ascending	Descending	Ascending	Descending
Ratio (Group 1/Group 2)	4.5	2.1	1.2	1.2

^aMean ED₅₀ in mg/kg (n = 8 [group 1] or 9 [group 2])

^b95% Confidence limits