Table 1.
Descriptives in the Longitudinal Study of Aging Twins (LSADT) and the 1905-birth-cohort
| LSADT cohort | 1905 cohort | |
|---|---|---|
| Age | 78.8 years (73–95) | 92–93 years |
| Number of individuals | 689 | 1381 |
| % Females | 66 | 69 |
| Obtained sec./tert. educational level (in %) | 289 (42) | 457 (33) |
| Married (in %) | 282 (41) | 148 (11) |
| Middle or higher social class (in %) | 209 (30) | 416 (30) |
| Mean composite cognitive score | 0.95 | 0.34 |
| SD composite cognitive score | 3.33 | 3.45 |
| Mean MMSE | 25.90 | 21.95 |
| SD Mean MMSE | 3.68 | 5.64 |
| Median MMSE | 27 | 23 |
| % Nonimpaired | 80.7 | 48.7 |
| % Mildly impaired | 15.3 | 32.0 |
| % Severely impaired | 4.0 | 19.4 |
| rs3810950 No. ind. AA/AG/GG | 420/203/38 | 798/455/55 |
| rs3810950 minor allele (A) frequency (%) | 21.10 | 21.60 |
| rs8178990 No. ind. CC/CT/TT | 569/103/0 | 1189/179/6 |
| rs8178990 minor allele (T) frequency (%) | 7.66 | 6.95 |
| APOE No. ind. --/ − ε4/ ε4 ε4 | 445/202/18 | 1267/334/20 |
| APOE ε4 non-carriers: | ||
| rs3810950 No. ind. AA/AG/GG | 265/150/25 | 623/350/43 |
| rs8178990 No. ind. CC/CT/TT | 372/66/0 | 923/133/5 |
| APOE ε4 carriers: | ||
| rs3810950 No. ind. AA/AG/GG | 152/52/13 | 175/105/12 |
| rs8178990 No. ind. CC/CT/TT | 179/35/0 | 266/46/1 |