Table 2.

Regression analysis of the effect of ChAT variants on cognitive composite scores and MMSE in the comprised LSADT and 1905-birth-cohort (N=2070). In single variation analysis an additive genetic model was applied. Haplotypes are defined by rs3810950 A/G and rs8178990 T/G

	Cognitive composite score reg. coef. (95% CI), p-value	MMSE reg. coef. (95% CI), p-value
rs3810950	−0.30 (−0.57; −0.02), 0.034	0.09 (−0.31;0.49), 0.43
rs8178990	−0.02 (−0.48;0.43), 0.92	0.05 (−0.67;0.57), 0.88
APOE ε4	−0.38 (−0.71; −0.06), 0.02	−0.65 (−1.12; −0,17), 0.007
APOE ε 4 carriers:
rs3810950	−0.50 (−0.97; −0.04), 0.033	0.28 (−0.46;1.02), 0.46
rs8178990	0.65 (−0.22;1.53), 0.14	0.97 (0.00;1,95), 0.05
APOE ε 4 non-carriers:
rs3810950	−0.23 (−0.56;0.10), 0.17	−0.01 (−0.47;0.46), 0.98
rs8178990	−0.26 (−0.79;0.26), 0.32	−0.41(−1.18;0.35), 0.29
Haplotypes:
GC	0.59 (0.03;1.16), 0.039	0.31 (−0.47;1.09), 0.43
AC	−0.30 (−0.62;0.3), 0.076	0.41 (−0.28;0.68), 0.41
GT	−0.09 (−0.55;0.37), 0.70	−0.10 (−0.75; 0.54), 0.76