Table 3.

Regression analysis of the effect of the rs3810950 variants on cognitive composite scores and MMSE in the age selected LSADT (73–83) cohort and the 1905-birth-cohort.

	LSADT cohort 73–83 years of age (n=573)		1905-birth-cohort 92–93 years of age (n=1381)
	Cognitive composite score reg. coef. (95% CI), p-value	MMSE reg. coef. (95% CI), p-value	Cognitive composite score reg. coef. (95% CI), p-value	MMSE reg. coef. (95% CI), p-value
Additive model:
rs3810950	−0.56 (−1.09; −0.02), 0.044	−0.29 (−0.87;0.28), 0.31	−0.12 (− −0.44;0.20), 0.46	0.26 (−0.27;0.80), 0.33
Genotype based model*:
rs3810950 AG	−0.59 (−1.25; −0.07), 0.080	−0.17 (−0.84;0.49), 0.60	0.00 (−0.40;0.41), 1.00	0.54 (− −0.11;1.20), 0.11
rs3810950 AA	−1.03 (−2.50;0.45), 0.17	−0.83 (−2.49;0.83), 0.33	−0.60 (−1.50;0.29), 0.19	−0.25 (−1.75;1.25), 0.74
APOE ε 4 carriers*:
rs3810950 AG	−0.18 (−1.20;0.84), 0.73	0.34 (−0.74;1.43), 0.53	−0.36 (−1.15;0.43), 0.37	1.16 (−0.18;2.50), 0.09
rs3810950 AA	−2.19 (−4.14;0.24), 0.028	−3.57 (−5.62; −1.51), 0.001	−0.21 (−1.58;1.16), 0.76	2.06 (−0.16;4.29), 0.07
APOE ε 4 non-carriers*:
rs3810950 AG	−0.83 (−1.67; −0.00), 0.05	−0.56 (−1.37;0.26), 0.18	0.11 (−0.37;0.58), 0.66	0.37 (−0.38;1.13), 0.33
rs3810950 AA	−0.42 (−2.21;1.37), 0.64	0.50 (−0.91;1.90), 0.49	−0.71 (−1.79;0.37), 0.20	−0.91 (−2.71;0.88), 0.32

^*References are rs3810950 GG and rs8178990 CC, respectively