Table 1.

ED₅₀ values for the ascending and descending limbs of the quinpirole dose-response curve for yawning

Day	Ascending	Descending	Ascending	Descending
	Water		Sucrose
7	0.020a (0.008–0.049)	0.156b (0.116–0.211)	0.010 (0.003–0.031)	0.123 (0.067–0.228)
14	0.018 (0.006–0.049)	0.151 (0.114–0.200)	0.014 (0.022–0.009)	0.139 (0.088–0.219)
21	0.015 (0.008–0.031)	0.123 (0.075–0.201)	0.011 (0.004–0.027)	0.135 (0.085–0.213)
28	0.013 (0.008–0.023)	0.142 (0.111–0.182)	0.007 (0.005–0.011)	0.091 (0.054–0.154)
35	0.011 (0.008–0.016)	0.140 (0.108–0.181)	0.007 (0.002–0.021)	0.098 (0.046–0.211)
42	0.013 (0.006–0.028)	0.160 (0.128–0.199)	0.004 (0.003–0.007)	0.107 (0.058–0.199)
49	(Antagonist experiment)
56	0.013 (0.009–0.019)	0.127 (0.090–0.182)	0.006 (0.003–0.013)	0.083 (0.045–0.156)
	Water		Water (sucrose history)
63	0.011 (0.006–0.019)	0.112 (0.072–0.175)	0.006 (0.003–0.012)	0.096 (0.050–0.183)
70	0.015 (0.009–0.025)	0.106 (0.071–0.156)	0.009 (0.005–0.015)	0.087 (0.050–0.152)
112	0.011 (0.005–0.022)	0.118 (0.075–0.184)	0.006 (0.003–0.010)	0.100 (0.060–0.168)

^aED₅₀ values (95% CL) for the ascending limb of the quinpirole dose-response curve for yawning in 6 rats

^bED₅₀ values (95% CL) for the descending limb of the quinpirole dose-response curve for yawning in 6 rats