Fig. 3.

Leoligin activates cholesteryl ester transfer protein in vivo. CETP transgenic mice (n = 5 in each group) were dosed orally with equal daily amounts of leoligin (black bars), or vehicle control (white bars) for 7 days. (A) The CETP activity was measured after these 7 days. There was a higher in vivo CETP activity in leoligin treated mice when compared to controls (p = 0.015). (B) The lipid profiles showed a trend to lower LDL-cholesterol levels in the leoligin treated animals (closed circles), when compared to controls (open squares). * indicates p-value <0.05.