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. 2011 Sep 29;134(11):3369–3383. doi: 10.1093/brain/awr250

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© The Author (2011). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Purkinje cell degeneration was patterned in the cerebellar vermis and hemispheres of Slc9a6^−/Ymice. (A) Calbindin is expressed in all Purkinje cells in wild-type mice. (B) Calbindin expression reveals parasagittal stripes in the vermis (red arrows) and hemispheres (red asterisks) of Slc9a6^−/Ymice. (C) Low power image of an Slc9a6^−/Yanimal illustrating: (i) the parasagittal pattern of surviving Purkinje cells in the hemispheres (each stripe is labelled with a red asterisk); and (ii) Purkinje cells in the central zone (CZ, lobules VI/VII) and nodular zone (NZ, lobules IX/X) are resistant to degeneration (white brackets). Scale bar: C = 1 mm (=500 µm for A and B). Cop = copula pyramidis; Pmd = paramedian lobule.