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. 2006 May 15;203(5):1259–1271. doi: 10.1084/jem.20052494

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Ionizing radiation alters the MHC class I–associated peptide profile and immunological responses. (A) Mass spectrometry profiles of double-charged peptides eluted from corresponding rpHPLC fractions from nonirradiated and irradiated cells as indicated. The peptides marked by an asterisk are observed in both profiles, whereas the arrow indicates peptide CGI-51 that is observed only in the peptide fraction after irradiation. (B) Peptide sequences from proteins induced by γ-radiation as determined by MS and the corresponding proteins. Note that all peptides contain the anchor residues for HLA-A1 (in bold). (C) Identification of CTLs recognizing HLA-A1 tetramers containing irradiation-induced peptides. Flow cytometric analysis of human blood mononuclear cells gated on CD5⁺ and CD4⁻/CD19⁻ TCRγδ⁻ staining (leftmost panel) to determine the CTL population.