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. 2006 Jun 12;203(6):1567–1578. doi: 10.1084/jem.20052217

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Deconstruction of CDR-H3 sequences containing the mutated iD D_H gene segment during progressive stages in B cell development. (top) The potential contribution of the germline sequence of the V_H gene segment, the iD D_H gene segment, and the four J_H gene segments to CDR-H3 length is illustrated. (bottom) The actual contribution of these components to 70 fraction B, 49 fraction C, 60 fraction D, 76 fraction E, and 71 fraction F sequences. All components are shown to scale. N addition at the D→J junction decreases from fraction C to D (P < 0.02). J_H sequence contribution increases from fraction B to E (P < 0.05). Other differences did not achieve statistical significance.