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. 2006 Jun 12;203(6):1567–1578. doi: 10.1084/jem.20052217

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — V_H 7183 and J_H gene segment use during B cell development. V_H 7183 and J_H use is reported as the percent of the sequenced population of unique, in-frame, open transcripts for Hardy fractions B (left) through F (right) according to the scheme of Hardy et al. (reference 13). Both V_H and J_H segments are arranged in germline order. The number of sequences analyzed is shown. (top) V_H 7183 and J_H use in homozygous ΔD-iD mice (ΔD-iD). (middle) V_H 7183 and J_H use in homozygous ΔD-DFL mice (ΔD-DFL). (bottom) V_H 7183 and J_H use in wild-type, homozygous IgM^a mice (WT). Significant differences between WT and ΔD-iD are labeled with asterisks (**, P < 0.01, ***, P < 0.001 etc.; χ²).