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. 2011 Jan 27;2011(1):184502. doi: 10.1155/2011/184502

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Copyright © 2011 Stephen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) A 4-year-old female presented with Tanner III-IV breast development and bone age advancement to 11 years of age. Leuprolide stimulation (stimulated luteinizing hormone of 28 mIu/mL) confirmed gonadotropin-dependent precocious puberty. (b) MRI revealed an isointense mass (arrow) consistent with the diagnosis of a pedunculated hypothalamic hamartoma. This young girl's puberty has been adequately suppressed with depot leuprolide without further bone age advancement, pubertal development, neurologic sequelae, or mass changes on serial MRIs.