Figure 6.

(a) Growth chart of a girl (solid circles) with a history of locally advanced retinoblastoma status post right eye enucleation, chemotherapy, and radiotherapy (39.6 Gy in 35 fractions) to the orbit, completed at the age of 17 months. Bone ages are represented by open triangles. She was diagnosed with growth hormone (GH) deficiency and then gonadotropin-dependent sexual precocity and treated with GH and depot leuprolide, respectively. The patient had menarche at age 8 and achieved a final height of 60 inches, well below mid-parental height (MPH). (b) The patient's identical twin sister (open circles) was already significantly taller by the age of 5 years. She had menarche at age 12 and achieved a final adult height of 63.75 inches.