Table 2.
Distribution of C4 polymorphisms in individuals with or without Graves' disease
| Variations | GD |
P value, individuala [OR (95%CI), individual]c |
P value b | OR (95%CI)d | |
|---|---|---|---|---|---|
| No, N (%) | Yes, N (%) | ||||
| C4 CNV | |||||
| 4 | 57 (35.6) | 314 (50.3) | 0.001 [10.994 (6.277-19.255)] | 0.002 | (Reference) |
| < 4 | 52 (32.5) | 134 (21.5) | 0.003 [0.512 (0.338-0.776)] | 0.389 (0.245-0.615) | |
| > 4 | 51 (31.9) | 176 (28.2) | 0.361 | 0.497 (0.317-0.780) | |
| C4A CNV | |||||
| 2 | 83 (51.9) | 395 (63.3) | 0.008 [1.732 (1.190-2.520)] | 0.011 | (Reference) |
| < 2 | 33 (20.6) | 79 (12.7) | 0.010 [0.584 (0.360-0.948)] | 0.509 (0.307-0.843) | |
| > 2 | 44 (27.5) | 150 (24.0) | 0.365 | 0.628 (0.404-0.977) | |
| C4B CNV | |||||
| 2 | 67 (41.9) | 377 (60.4) | 2.420 × 10-5 [2.621 (1.791-3.835)] | 1.328 × 10-4 | (Reference) |
| < 2 | 53 (33.1) | 143 (22.9) | 0.008 [0.487 (0.322-0.738)] | 0.374 (0.240-0.584) | |
| > 2 | 40 (25) | 104 (16.7) | 0.015 [0.545 (0.347-0.856)] | 0.391 (0.241-0.636) | |
| C4 polymorphisms | |||||
| A2B2 | 39 (24.4) | 254 (40.7) | 1.395 × 10-4 [2.671 (1.761-4.052)] | 3.87 × 10-6 | (Reference) |
| A2B1 | 22 (13.8) | 78 (12.5) | 0.672 | 0.409 (0.219-0.763) | |
| A3B2 | 16 (10.0) | 64 (10.3) | 0.924 | 0.539 (0.273-1.064) | |
| A2B3 | 5 (3.1) | 44 (7.1) | 0.067 | 0.961 (0.343-2.697) | |
| A3B1 | 10 (6.3) | 32 (5.1) | 0.574 | 0.373 (0.159-0.876) | |
| A1B2 | 6 (3.8) | 34 (5.4) | 0.384 | 0.687 (0.257-1.836) | |
| Other | 62 (38.8) | 118 (18.9) | 0.242 (0.148-0.396) | ||
Abbreviations: GD, Graves' disease; CNV, copy number variation; OR, odds ratio; CI, confidence interval; N, number.
aIndividual C4 CNVs and polymorphisms between individuals with or without GD were evaluated by Fisher's exact test using 2 × 2 contingency tables.
b CNV of C4, C4A and C4B between individuals with or without GD were evaluated by Fisher's exact test using 3 × 2 contingency tables.C4 polymorphisms between individuals with or without GD were evaluated by Fisher's exact test using 7 × 2 contingency tables. The p value was estimated by 100,000 Monte Carlo simulations with 99% confidence intervals (CI).
cORs and 95% CIs were estimated from logistic regression models adjusting for age.
dORs and 95% CIs were estimated from logistic regression models adjusting for age.