Figure 4.

Dysregulation of miR-29/YY1 circuit in rhabdomyosarcoma cells. Upper panel, During muscle tissue formation, in normal myogenic precursor cells miR-29b2/miR-29c targets the 3'UTR of YY1 mRNA inhibiting its expression. Lower panel, Conversely, in rhabdomyosarcoma (RMS) cells NF-kB is up-regulated and YY1 over-produced. The high amount of YY1 in RMS cells is able to recruit EZH2 and HDAC1 on the promoter of miR-29 gene blocking its transcription thus resulting in uncontrolled cell proliferation.