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. Author manuscript; available in PMC: 2011 Nov 10.
Published in final edited form as: Stroke. 2010 Oct;41(10 Suppl):S45–S49. doi: 10.1161/STROKEAHA.110.595157

Figure 1.

Figure 1

Schematic representation of mode of action of systemic (intravenous) and local (intra-arterial) administration of plasminogen activators (e.g., tPA) and plasmin. Modified from Marder and Novokhatny4. The top panel shows systemic (intravenous) administration, and the bottom panel shows local (catheter) administration of tissue-type plasminogen activator (t-PA) (left) and plasmin (right), as typical representatives of direct and indirect fibrinolytic agents. PAI-1, plasminogen activator inhibitor type 1.