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Dose considerations for plasmin in human ischemic stroke.
| RABBIT | HUMAN | IMPLICATION | |
|---|---|---|---|
| BODY WEIGHT | 4 kg | 70-80 kg | 20-fold higher dose needed in humans (20 mg vs 1 mg) |
| THROMBUS HISTOLOGY |
Simple whole blood clot |
Mature, complex thrombo-embolus |
More plasmin needed in humans than on weight basis alone. |
| DELAY UNTIL RECANALIZATION |
20-25 min from start of infusion |
t-PA infusion time 60 min |
Plasmin infusion time of 30 min (early look at 15 min). |
