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. 2011 Sep 23;26(12):3249–3263. doi: 10.1093/humrep/der317

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© The Author 2011. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

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Oxamate reduces motility, hyperactivation and endogenous ATP in human spermatozoa in a dose-dependent manner. Purified human spermatozoa were incubated under conditions promoting capacitation for 120 min in the presence of increasing concentrations (A–D: 39 µM–40 mM, E: 3.6 µM–15 mM) of oxamate. Effects of oxamate on sperm cell motility were determined by CASA as (A) motility (%), (B) progressive motility (%), (C) VCL (µm/s) and (D) hyperactive motility (%). (E) ATP concentrations measured by luminescence. All data sets are presented as mean ± SEM from three (A–D; n= 6) and four (E; n= 8) separate experiments.