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Operational stability of the lipase-immobilized silica monolith bioreactor in the continuous production of biodiesel. The substrate solution, composed of methanol and oil at 3:1 molar ratio and 0.6% (w/w) water, was fed continuously at a constant flow rate of 0.06 mL/h to the bioreactor (10 mm × 10 cm) loaded with 1.87 g silica monolith containing 0.63 g lipase.
