Table 3.
Univariate and multivariate contribution of fibrinogen, platelets, FXIII and sCD40L to the variation in TEG maximum amplitude (MA) in trauma patients stratified according to ISS (gr. 2 ISS > 26, gr. 1 ISS 15-26, gr. 0 ISS < 15)
| Univariate | Multivariate (model 1) | Multivariate (model 2) | |||||
|---|---|---|---|---|---|---|---|
| Unit | β (SE) | p | β (SE) | p | β (SE) | p | |
| ISS > 26 (n = 23) | R2 = 0.47 | R2 = 0.76 | |||||
| Fibrinogen | 1 g/l | 6.59 (1.85) | 0.002 | 5.61 (1.86) | 0.007 | 4.65 (1.31) | 0.002 |
| Platelets | 10 *109/l | 0.48 (0.28) | 0.094 | 0.29 (0.25) | 0.438 | 0.42 (0.18) | 0.032 |
| FXIII | 1% | 0.43 (0.20) | 0.043 | 0.24 (0.19) | 0.212 | 0.17 (0.13) | 0.210 |
| sCD40L | 100 pg/ml | -1.62 (0.53) | 0.006 | - | - | -1.62 (0.35) | < 0.001 |
| ISS 15-26 (n = 26) | R2 = 0.75 | R2 = 0.76 | |||||
| Fibrinogen | 1 g/l | 6.84 (1.08) | < 0.001 | 6.33 (0.96) | < 0.001 | 5.84 (1.04) | < 0.001 |
| Platelets | 10 *109/l | 0.41 (0.20) | 0.047 | 0.37 (0.13) | 0.011 | 0.44 (0.14) | 0.006 |
| FXIII | 1% | 0.13 (0.11) | 0.245 | 0.01 (0.07) | 0.847 | 0.03 (0.07) | 0.712 |
| sCD40L | 100 pg/ml | -0.95 (0.89) | 0.300 | - | - | -0.73 (0.61) | 0.250 |
| ISS < 15 (n = 30) | R2 = 0.41 | R2 = 0.41 | |||||
| Fibrinogen | 1 g/l | 3.55 (1.12) | 0.004 | 3.26 (1.05) | 0.005 | 3.29 (1.07) | 0.005 |
| Platelets | 10 *109/l | 0.34 (0.13) | 0.017 | 0.30 (1.05) | 0.019 | 0.28 (0.13) | 0.038 |
| FXIII | 1% | 0.00 (0.04) | 0.986 | 0.00 (0.03) | 0.995 | -0.00 (0.03) | 0.984 |
| sCD40L | 100 pg/ml | 0.38 (0.44) | 0.403 | - | - | 0.15 (0.38) | 0.691 |
Univariate and multivariate regression analysis showing regression coefficients (β) with standard errors (SE) and p-values, with p-values in bold for variables with p < 0.05. The β corresponds to the predicted change in TEG MA (mm) associated with one unit increase in fibrinogen, platelet count, FXIII and/or sCD40L.