Table 3.
Genetic risk profile using CARD15/NOD2, IL23R, PTGER4, and IRGM susceptibility alleles.
| Risk profile | N (%) | OR (95% CI) | P | Sensitivity | Specificity | PPV | NPV | Accuracy | |
|---|---|---|---|---|---|---|---|---|---|
| CD | Control | ||||||||
| Number of risk alleles | |||||||||
| ≥3 | 366 (99) | 489 (97) | 3.49 (0.99-12.24) | 0.05 | 99.2 | 2.8 | 42.8 | 82.4 | 43.6 |
| ≥4 | 354 (96) | 425 (84) | 4.33 (2.48-7.66) | 5.80*10-8 | 95.9 | 15.5 | 45.4 | 83.9 | 49.5 |
| ≥5 | 316 (86) | 310 (62) | 3.71 (2.64-5.23) | 3.95*10-15 | 85.6 | 38.4 | 50.5 | 78.5 | 58.4 |
| ≥6 | 214 (58) | 152 (30) | 3.19 (2.41-4.22) | 1.94*10-16 | 57.9 | 69.8 | 58.5 | 69.4 | 64.5 |
| ≥7 | 107 (29) | 39 (8) | 4.86 (3.27-7.22) | 9.88*10-17 | 29.0 | 92.2 | 73.3 | 63.9 | 65.5 |
| ≥8 | 27 (7) | 3 (0.6) | 13.16 (3.96-43.72) | 4.29*10-8 | 7.3 | 99.4 | 90.0 | 59.4 | 60.4 |
| Weighted Score | |||||||||
| ≥2 | 368 (>99) | 498 (99) | 3.69 (0.43-31.75) | 0.25 | 99.7 | 1.0 | 42.5 | 83.3 | 42.8 |
| ≥3 | 361 (99) | 470 (93) | 3.17 (1.45-6.94) | 0.003 | 97.8 | 6.6 | 43.4 | 80.5 | 45.2 |
| ≥4 | 331 (90) | 377 (75) | 2.91 (1.97-4.31) | 4.13*10-8 | 89.7 | 25.0 | 46.8 | 76.8 | 52.4 |
| ≥5 | 287 (78) | 259 (51) | 3.30 (2.44-4.46) | 2.42*10-15 | 77.8 | 48.5 | 52.6 | 74.8 | 60.9 |
| ≥6 | 216 (59) | 138 (27) | 3.73 (2.81-4.97) | 1.97*10-20 | 58.5 | 72.6 | 61.0 | 70.5 | 66.6 |
| ≥7 | 174 (47) | 88 (17) | 4.21 (3.09-5.72) | 3.65*10-21 | 47.2 | 82.5 | 66.4 | 68.0 | 67.5 |
| ≥8 | 124 (34) | 42 (8) | 5.56 (3.79-8.15) | 5.14*10-21 | 33.6 | 91.7 | 74.7 | 65.3 | 67.1 |
| ≥9 | 108 (29) | 27 (5) | 7.69 (4.89-12.11) | 3.49*10-23 | 29.3 | 94.6 | 80.0 | 64.6 | 67.0 |
| ≥10 | 73 (20) | 20 (4) | 9.45 (5.15-17.34) | 5.74*10-18 | 19.8 | 96.0 | 78.5 | 62.0 | 63.8 |
| ≥11 | 53 (14) | 13 (3) | 14.2 (6.04-33.40) | 1.76*10-15 | 14.4 | 97.4 | 80.3 | 60.8 | 62.3 |
OR (95% CI), Odds ratio (95% confidence interval); PPV, Positive predictive value; NPV, Negative predictive value.