Table III.

Summary of results from immunohistochemical evaluation of REGIα levels in biopsies.

		IHC evaluated REGIα level
Sample Group	Number of samples	P	0	1	2	3	Mean REGIα level	Differnt from normal group (p value)
N	23	1	22	0	0	0	0.0	–
CDN	21	5	14	0	1	1	0.4	NS
UCN	34	4	27	1	1	1	0.2	NS
UPN	13	3	10	0	0	0	0.1	NS
CDD	12	1	3	1	5	2	1.5	<0.01
UCD	32	2	5	5	13	8	1.7	<0.01
UPD	11	0	2	4	3	2	1.4	<0.01

N = healthy controls; CDN, UCN, or UPN = histologically normal mucosa from patients with known Crohn's disease, ulcerative colitis, or ulcerative proctitis; CDD, UCD, or UPD – histologically diseased mucosa from patients with Crohn's disease, ulcerative colitis, or ulcerative proctitis.

REGIα expression level: “P": only Paneth cells were stained, “0” to “3": an increasing level of staining. 0: No staining; 1: <20% of crypt epithelial cells stained; 2: 20-50% of crypt epithelial cells stained; 3: >50% of crypt epithelial cells stained. Difference from normal group is evaluated using two-tailed Welch t-test and result given as the p value for this test.