Table 1.
Baseline characteristics of the patients randomized to carvedilol, metoprolol succinate and metoprolol tartrate before and after the treatment period, and baseline characteristics of the healthy control group
| Carvedilol (N = 9) |
Metoprolol Succinate (N = 9) |
Metoprolol Tartrate (N = 9) |
Healthy controls (N = 10) |
||||
|---|---|---|---|---|---|---|---|
| Before treatment | After treatment | Before treatment | After trreatment | Before treatment | After treatment | ||
| Age | 67.1 ± 3.31 | 63.6 ± 2.02 | 60.3 ± 3.26 | 47.6 ± 1.89 | |||
| Sex (Female/Male) | 2/7 | 2/7 | 1/8 | 5/5 | |||
| Smokers (Y/N) | 4/5 | 1/8 | 2/7 | 0 | |||
| Diabetes (Y/N) | 3/6 | 3/6 | 0/9 | 0 | |||
| NYHA I (N°) | 5 | 4 | 5 | 0 | |||
| NYHA II (N°) | 4 | 5 | 4 | 0 | |||
| ACE I/ATII ant (Y/N) | 9/0 | 7/2 | 5/4 | 0 | |||
| Aspirin (Y/N) | 6/3 | 6/3 | 7/2 | 0 | |||
| Statins (Y/N) | 7/2 | 8/1 | 7/2 | 0 | |||
| CRP | < 10 | < 10 | < 10 | < 10 | < 10 | < 10 | < 10 |
| Hgb (mmol/l) | 8.1 ± 0.30 | 7.97 ± 0.34 | 8.48 ± 0.23 | 8.37 ± 0.33 | 8.54 ± 0.19 | 8.47 ± 0.16 | 8.00 ± 0.21 |
| Total Cholesterol (mmol/l) | 3.88 ± 0.23 | 3.89 ± 0.30 | 4.21 ± 0.27 | 3.96 ± 0.22 | 3.88 ± 0.18 | 3.81 ± 0.19 | 4.5 ± 0.29 |
| Triglyceride (mmol/l) | 1.57 ± 0.40 | 1.35 ± 0.20 | 1.66 ± 0.41 | 1.74 ± 0.31 | 1.57 ± 0.38 | 1.57 ± 0.36 | 0.9 ± 0.17 |
| HDL (mmol/l) | 1.47 ± 0.20 | 1.24 ± 0.203 | 1.44 ± 0.16 | 1.15 ± 0.113 | 1.34 ± 0.12 | 1.27 ± 0.13 | 1.4 ± 0.14 |
| LDL (mmol/l) | 1.88 ± 0.17 | 2.03 ± 0.24 | 2.24 ± 0.31 | 2.03 ± 0.24 | 1.80 ± 0.24 | 1.88 ± 0.27 | 2.7 ± 0.26 |
| Hgb A1c (%) | 6.12 ± 0.20 | 5.91 ± 0.233 | 6.78 ± 0.49 | 6.73 ± 0.51 | 5.64 ± 0.10¹2 | 5.5 ± 0.252 | 5.24 ± 0.10 |
| Plasma-Glucose | 6.30 ± 0.29 | 6.24 ± 0.69 | 5.73 ± 0.42 | 5.82 ± 0.49 | 5.19 ± 0.26¹ | 5.14 ± 0.31 | |
| Serum-Insulin | 24.80 ± 11.72 | 27.50 ± 12.96 | 9.72 ± 2.52 | 17.67 ± 4.71 | 8.52 ± 2.93 | 8.32 ± 3.48 | |
| HOMA-IR | 1.86 ± 0.67 | 1.77 ± 0.37 | 1.33 ± 0.34 | 1.87 ± 0.62 | 1.11 ± 0.40 | 1.33 ± 0.56 | |
| Body weight (kg) | 77.58 ± 6.60 | 77.47 ± 6.74 | 90.21 ± 6.17 | 90.19 ± 6.40 | 86.82 ± 3.53 | 87.59 ± 3.99 | 75.62 ± 4.24 |
| BMI (kg/m2) | 26.37 ± 1.23 | 26.32 ± 1.27 | 29.41 ± 1.63 | 29.38 ± 1.65 | 28.1 ± 0.84 | 28.31 ± 0.98 | 24.4 ± 0.93 |
¹p < 0.05 for comparison between metoprolol tartrate and carvedilol
2p < 0.05 for comparison between metoprolol tartrate and metoprolol succinate
3p < 0.05 change from before and after randomization treatment