Table 1.
Analysis of cell compartment enrichment in the BIOGRID database.
| GO ID | GO Term | Median p-value |
|---|---|---|
| Overrepresented categories: | ||
| 32991 | macromolecular complex | 4.96E-105 |
| 43234 | protein complex | 1.80E-78 |
| 44428 | nuclear part | 1.06E-66 |
| 5622 | intracellular | 2.74E-54 |
| 44424 | intracellular part | 3.72E-53 |
| 44422 | organelle part | 8.61E-51 |
| 44446 | intracellular organelle part | 8.61E-51 |
| 5634 | nucleus | 2.43E-52 |
| 43229 | intracellular organelle | 8.85E-48 |
| 43226 | organelle | 8.85E-48 |
| 31981 | nuclear lumen | 1.27E-53 |
| 44451 | nucleoplasm part | 5.98E-38 |
| 5654 | nucleoplasm | 1.75E-38 |
| 44464 | cell part | 3.54E-33 |
| 5623 | cell | 4.46E-33 |
| 43228 | non-membrane-bounded organelle | 1.67E-34 |
| 43232 | intracellular non-membrane-bounded organelle | 1.67E-34 |
| 43233 | organelle lumen | 1.02E-31 |
| 31974 | membrane-enclosed lumen | 1.02E-31 |
| 43231 | intracellular membrane-bounded organelle | 4.99E-31 |
| 43227 | membrane-bounded organelle | 4.99E-31 |
| 16591 | DNA-directed RNA polymerase II, holoenzyme | 4.98E-11 |
| 5694 | chromosome | 7.67E-15 |
| 30529 | ribonucleoprotein complex | 2.76E-12 |
| 5730 | nucleolus | 6.52E-13 |
| 502 | proteasome complex | 2.37E-06 |
| 44427 | chromosomal part | 1.61E-14 |
| 5856 | cytoskeleton | 3.25E-07 |
| 5679 | chromatin remodeling complex | 1.70E-09 |
| 123 | histone acetyltransferase complex | 5.87E-10 |
| 44430 | cytoskeletal part | 1.65E-05 |
| 22624 | proteasome accessory complex | 9.47E-04 |
| 5838 | proteasome regulatory particle | 9.47E-04 |
| 44452 | nucleolar part | 2.30E-08 |
| 5669 | transcription factor TFIID complex | 7.26E-03 |
| 5681 | spliceosome | 4.85E-04 |
| 119 | mediator complex | 3.91E-04 |
| 124 | SAGA complex | 1.04E-05 |
| 5667 | transcription factor complex | 3.06E-04 |
| 812 | SWR1 complex | 1.15E-03 |
| 44453 | nuclear membrane part | 6.00E-03 |
| Underrepresented categories: | ||
| 943 | retrotransposon nucleocapsid | 2.88E-05 |
| 31224 | intrinsic to membrane | 1.22E-05 |
| 44429 | mitochondrial part | 3.18E-04 |
| 5740 | mitochondrial envelope | 4.89E-03 |
| 16021 | integral to membrane | 7.67E-05 |
| 44425 | membrane part | 1.85E-03 |
| 5743 | mitochondrial inner membrane | 7.18E-03 |
| 5739 | mitochondrion | 6.34E-03 |
The median p-values were calculated after sampling 10 random sets of 1000 interactions from BIOGRID. P-values are shown after Bonferroni's correction for multiple hypotheses.