Figure 3.

Yeast protein-protein interaction networks. A) Network of proteins whose absence or reduced levels render cells sensitive to MMS B) Sub-network of these proteins involved in RNA processing. Non-essential proteins are in red, essential proteins in green. The size (inverse to the GI₅₀-value) reflects the sensitivity to MMS of the corresponding yeast strains. Classification of severe, intermediate and slight sensitivity was established according to GI₅₀ values (GI₅₀<0.003%, GI₅₀<0.006% and GI₅₀<0.008%, respectively).