Demographic
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|
|
Female/male gender |
80/69 |
|
45/39 |
|
1.0 |
33/40 |
|
70/96 |
|
0.7 |
Median age (range) in years |
2.1 |
(0.5–4.9) |
2.5 |
(0.6–4.9) |
0.03 |
2.2 |
(0.5–4.8) |
2.8 |
(0.5–4.9) |
<0.001 |
Median weight (range) in kg |
10.1 |
(6.3–19.4) |
11.1 |
(6.2–20.7) |
0.04 |
10.5 |
(6.4–17.0) |
11.6 |
(6.4–18.0) |
<0.001 |
Clinical
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Median axillary temperature (range) in °C |
37.3 |
(36.0–40.1) |
38.0 |
(36.2–40.5) |
<0.001 |
37.3 |
(35.6–39.4) |
37.9 |
(35.9–41.4) |
<0.001 |
Mean heart rate (SD) in bpm |
143 |
(25) |
143 |
(20) |
0.7 |
149 |
(21) |
147 |
(23) |
0.8 |
Parasitological
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Mean number of previous P. falciparum malaria episodes (N; range) |
2.5 |
(69; 0–15) |
1.5 |
(45; 0–7) |
0.2 |
1.6 |
(29; 0–7) |
2.0 |
(91; 0–12) |
0.5 |
Median asexual P. falciparum density (range) in parasites/µL |
34,600 |
(2,200–218,000) |
36,600 |
(2,200–290,000) |
0.8 |
44,500 |
(2,400–350,000) |
57,600 |
(2,100–862,000) |
0.07 |
Proportion of patients with gametocytes (%) |
4/149 |
(3%) |
1/84 |
(1%) |
0.7 |
1/73 |
(1%) |
2/167 |
(1%) |
1.0 |
Multiplicity of infection (number of clones, SD) |
2.1 |
(1.2) |
2.8 |
(1.2) |
0.003 |
1.7 |
(0.7) |
2.7 |
(1.2) |
0.004 |
Infections with >1 genomic copy of MDR1
|
0/45 |
(0%) |
0/28 |
(0%) |
1.0 |
0/23 |
(0%) |
2/62 |
(3%) |
1.0 |
Hematology
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Mean hemoglobin concentration (SD) in g/dL |
9.0 |
(1.6) |
9.2 |
(1.8) |
0.4 |
8.8 |
(1.3) |
9.2 |
(1.6) |
0.03 |
Median neutrophil count (range) in 103 cells/µL |
3.5 |
(0.6–15.5) |
3.3 |
(1.3–16.5) |
0.9 |
3.6 |
(1.0–17.5) |
3.7 |
(0.5–13.1) |
0.6 |
Median platelet count (range) in 103 cells/µL |
166 |
(14–557) |
154 |
(45–420) |
0.7 |
114 |
(9–483) |
142 |
(2–445) |
0.8 |
Clinical chemistry
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Medium serum ALT level (range) in IU/L |
22 |
(8–330) |
21 |
(9–173) |
0.7 |
23 |
(9–230) |
23 |
(8–844) |
0.5 |
Medium serum creatinine (range) in µmol/L |
41 |
(3–73) |
40 |
(24–67) |
0.9 |
39 |
(22–58) |
40 |
(20–71) |
0.3 |
Medium serum bilirubin (range) in µmol/L |
13 |
(2–142) |
12 |
(2–58) |
0.1 |
16 |
(2–71) |
16 |
(1–126) |
0.8 |