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. 2011 Jul 13;12:284. doi: 10.1186/1471-2105-12-284

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Copyright ©2011 Rakovski et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DNA methylation of MLH1 in the Colon-CFR. A) Scatterplot of MLH1 Percent Methylated Reference (PMR) against ALU C(t) value for 198 MSI-H colon cancer samples from Seattle. (a)-(e) Histograms of the PMR values by 5 quintiles of ALU C(t). B) a plot of SD of MLH1 PMR by quintile of ALU C(t) (grey bars) and by sliding windows (black circles). C) Back-to-back histograms of the MLH1 PMR in females and males for 198 MSI-H tumors from the Colon CFR (Seattle site). One sample with a PMR = 302 lies outside the range of the figure. Black dots denote the overall mean (including the sample not displayed.)