Table 1.

The distribution of methylation proportion by patient subgroup (Group 1, Group 2), in the simulation study

	Bernoulli Proportion 1	Beta distribution 2
		Mean	Var
Scenario	(Group 1, Group 2)	(Group 1, Group 2)	(Group 1, Group 2)	Difference in Overall Means	Difference in Overall Vars 3
a.i	(1,1)	(0.2, 0.27)	(0.01, 0.01)	0.07	0
a.ii			(0.04, 0.04)	0.07	0
a.iii			(0.01, 0.04)	0.07	0.3
b.i		(0.4, 0.47)	(0.01, 0.01)	0.07	0
b.ii			(0.04, 0.04)	0.07	0
b.iii			(0.01, 0.04)	0.07	0.3
c.i	(0.5,0.7)	(0.4, 0.47)	(0.01, 0.01)	0.13	0.01
c.ii			(0.04, 0.04)	0.13	0.01
c.iii			(0.01, 0.04)	0.13	0.02

¹ The probability that the true methylation proportion is positive

² Distribution of the true methylation proportion in methylated tumors

³ Estimated from the data.