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Nicotine increases the frequency not the amplitude of spontaneous EPSCs recorded from VTA DA neurons. Example traces (upper) show that bath-applied nicotine (500 nM) increases the frequency of sEPSCs, and the average (eight of 12; four showed no change) shows the long-lasting effect of the frequency increase (lower). The recordings were at room temperature, at a holding potential of –60 mV. Scale bars represent 10 pA and 500 msec.
