Figure 7.

The β2* antagonist, DHβE, decreased the amplitude of GABAa-evoked IPSCs onto DA neurons. Example traces (upper) show that bath-applied DHβE (1 μM) decreases the amplitude of eIPSCs, and the average (four out of 10 neurons; six showed no effect) shows the amplitude decrease (lower). The α7* nAChR antagonist, MLA, had no effect in separate experiments (data not shown) or when applied before DHβE. The recordings were at room temperature at a holding potential of –60 mV, and weak simulation strength was used. The scale bars represent 50 pA and 20 msec.