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. 2011 Nov 10;7(11):e1002362. doi: 10.1371/journal.pgen.1002362

Figure 5. Microarray analysis reveals induction of cell-cycle gene transcripts in differentiated muscle cells.

Figure 5

(A,B) Functional annotation of genes significantly increased more than 2-fold in Pmyo-3::CYD-1/CDK-4 and Pmyo-3::CYE-1/CDK-2AF muscle cells. A large overrepresentation of genes involved in various stages of the cell cycle is seen in both data sets, as well as a distinct increase in the proportion of metabolism and signaling genes in CYD-1/CDK-4 animals. (C) Overlap in more than 2-fold upregulated genes between CYE-1/CDK-2AF and CYD-1/CDK-4 body-wall muscle cells. The majority of the genes induced by CYE-1/CDK-2AF are also induced in CYD-1/CDK-4, but the latter also contains a substantial number of non-cell cycle genes. (D) Functional annotation of the genes present in the overlap between CYD-1/CDK-4 and CYE-1/CDK-2AF reveals a strong (60%) representation of known cell cycle genes. (E) Table of representative cell cycle genes and their orthologs that are induced by both CYD-1/CDK-4 and CYE-1/CDK-2AF (>2-fold upregulated).