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. 2011 Nov 10;7(11):e1002271. doi: 10.1371/journal.pcbi.1002271

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Jilkine et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Illustration shows stability of equilibrium values for cytosolic densities, and , for varying when . Red: stable root; black unstable root. (B) Shown is equilibrium membrane fraction of signaling molecules on the membrane for various cell densities and different values of . Cytosolic buffering occurs when is nearly zero. (C) The probability, , that the: cytosol contains exactly molecules is shown for different total molecule numbers, , scanned between 0 and . Steady state probabilities of molecule numbers in the cytosol are computed from stochastic master equation (Protocol S1). Inset: zoom-in of transition region showing bimodality of probability distribution.

Inline graphic — (A) Illustration shows stability of equilibrium values for cytosolic densities, and , for varying when . Red: stable root; black unstable root. (B) Shown is equilibrium membrane fraction of signaling molecules on the membrane for various cell densities and different values of . Cytosolic buffering occurs when is nearly zero. (C) The probability, , that the: cytosol contains exactly molecules is shown for different total molecule numbers, , scanned between 0 and . Steady state probabilities of molecule numbers in the cytosol are computed from stochastic master equation (Protocol S1). Inset: zoom-in of transition region showing bimodality of probability distribution.