Table 4.
Association between severe dyspeptic symptoms and HTR3A c.-42C > T genotype stratified by gender and 5-HTTLPR genotype
| Severe dyspeptic symptoms | HTR3A c.-42C>T | OR (95% CI) * | P value | ||
|---|---|---|---|---|---|
| CC | CT + TT | ||||
| Gender | |||||
| Female | Yes | 56 (49.6) | 57 (50.4) | 2.05 (1.25-3.39) | 0.005 |
| No | 137 (65.6) | 72 (34.4) | |||
| Male | Yes | 52 (61.9) | 32 (38.1) | 0.86 | |
| No | 117 (62.9) | 69 (37.1) | 1.05 (0.60-1.84) | ||
| 5-HTTLPR | |||||
| LL | Yes | 31 (52.5) | 28 (47.5) | 2.00 (1.01-3.94) | 0.046 |
| No | 77 (69.4) | 34 (30.6) | |||
| LS + SS | Yes | 77 (55.8) | 61 (44.2) | 0.15 | |
| No | 177 (62.3) | 107 (37.7) | 1.38 (0.88-2.15) | ||
Genotype distributions are depicted as number (%).
*adjusted for age, IBS status, psycho neuroticism, use of anti depressive and acid suppressive medication and active coping style