Table 1.
Baseline characteristics of participants in study monitoring efficacy of ART, Tororo and Busia Districts, Uganda, 2003-7, according to type of monitoring: viral load arm (clinical monitoring, CD4 cell count, viral load monitoring), CD4 arm (clinical monitoring, CD4 cell count), and clinical arm (clinical monitoring only). Figures are numbers (percentage) of patients unless stated otherwise
| Viral load arm (n=368) | CD4 arm (n=371) | Clinical arm (n=377) | P value* | |
|---|---|---|---|---|
| Median (IQR) age (years) | 37 (32-43.5) | 38 (32-44) | 39 (32-44) | 0.96 |
| Female (%) | 75 | 75 | 67 | 0.01 |
| CD4 cell count in cells × 106/L (IQR): | ||||
| Median | 128 (61-194) | 127 (62-130) | 131 (70-197) | 0.65 |
| <50 | 78 (21) | 76 (20) | 67 (18) | — |
| 50-200 | 209 (57) | 219 (59) | 223 (59) | — |
| >200 | 80 (22) | 76 (20) | 87 (23) | — |
| HIV viral load (copies/mL): | ||||
| Median (IQR) | 233 000 (77 900-513 000) | 201 000 (63 600-520 000) | 210 000 (74 600-570 000) | 0.63 |
| <1000 | 1 (0) | 3 (1) | 4 (1) | — |
| 1000-9999 | 16 (4) | 11 (3) | 15 (4) | — |
| 10 000-99 999 | 97 (26) | 115 (31) | 95 (25) | — |
| ≥100 000 | 253 (69) | 242 (65) | 263 (70) | — |
| Mean log10 copies/mL | 5.2 | 5.2 | 5.2 | 0.84 |
| Body mass index: | ||||
| Median (IQR) | 19.7 (18-21.5) | 19.7 (18.1-21.5) | 19.6 (18.0-21.5) | 0.98 |
| <18.5 | 111 (30) | 113 (30) | 114 (30) | |
| 18.5-24.9 | 218 (59) | 228 (61) | 238 (63) | |
| 25-29.9 | 20 (5) | 14 (4) | 12 (3) | |
| ≥30 | 3 (1) | 4 (1) | 3 (1) | |
| Missing | 16 (4) | 12 (3) | 10 (3) | |
| Median haemoglobin (g/L) | 112 | 112 | 112 | 0.96 |
| Aspartate aminotransferase (AST) >1.5 times normal (%) | 31 (8) | 33 (9) | 32 (8) | 0.55 |
| Alanine aminotransferase (ALT) >1.5 times normal (%) | 9 (2) | 9 (2) | 16 (4) | 0.28 |
| Creatinine >132.6 µmol/L) (%) | 6 (2) | 11 (3) | 10 (3) | 0.38 |
| Highest level of education completed: | ||||
| None | 198 (54) | 205 (55) | 182 (48) | 0.48 |
| Primary | 80 (22) | 70 (19) | 82 (22) | |
| More than primary | 80 (22) | 83 (22) | 98 (26) | |
| Missing | 10 (3) | 13 (4) | 15 (4) | |
| Marital status: | ||||
| Single | 15 (4) | 16 (4) | 17 (5) | 0.46 |
| Married/cohabiting | 142 (39) | 127 (34) | 149 (40) | |
| Separated/divorced | 31 (8) | 49 (13) | 42 (11) | |
| Widowed | 170 (46) | 166 (45) | 154 (41) | |
| Missing | 10 (3) | 13 (4) | 15 (4) | |
| Received ART for PMTCT in past (women only) | 5 (2) | 3 (1) | 4 (2) | 0.77 |
| In per protocol analysis | 349 (95) | 346 (93) | 352 (93) | 0.61 |
IQR=interquartile range; PMTCT=preventing mother to child transmission.
*Kruskal-Wallis test for continuous variables or χ2 or Fisher’s exact test for categorical variables.