TABLE 6.

Sensitivity analyses for primary outcome

Restricted analysis	IBD	UC	CD
	HR (95% CI)	HR (95% CI)	HR (95% CI)
More stringent IBD definition*	0.81 (0.69, 0.94)	0.74 (0.60, 0.91)	0.88 (0.70, 1.10)
Age 35-50 only	0.77 (0.61, 0.99)	0.71 (0.50, 1.00)	0.88 (0.62, 1.24)
Exclude CAD	0.82 (0.70, 0.95)	0.77 (0.62, 0.95)	0.91 (0.72, 1.14)
Exclude DM	0.87 (0.74, 1.02)	0.86 (0.70, 1.07)	0.89 (0.70, 1.13)
Exclude Stroke	0.82 (0.71, 0.95)	0.74 (0.61, 0.91)	0.93 (0.76, 1.15)
Exclude CAD, DM, or stroke†	0.87 (0.73, 1.04)	0.86 (0.68, 1.09)	0.92 (0.71, 1.19)
Exclude statin ≤30 days	0.81 (0.70, 0.93)	0.75 (0.61, 0.91)	0.88 (0.71, 1.09)
Exclude pre-exposure steroids	0.95 (0.77, 1.18)	0.92 (0.69, 1.24)	1.03 (0.74, 1.43)
Exclude pre-exposure hospitalization	0.80 (0.68, 0.94)	0.76 (0.61, 0.95)	0.87 (0.69, 1.10)
Charlson index <2	0.82 (0.70, 0.96)	0.77 (0.63, 0.96)	0.87 (0.69, 1.10)

^*Definition included at least 4 diagnosis claims for IBD in addition to at least 1 IBD-related prescription

^†Any subject with a diagnosis claim for coronary artery disease, diabetes, or stroke in the 180 day pre-exposure period was excluded

HRs were determined via Cox proportional hazard models, adjusting for potential confounders including including Charlson comorbidity index, pre-exposure use of aminosalicylates, 6MP or azathioprine, rectal steroids, outpatient contacts and hospitalizations prior to exposure.

HR: Hazard ratio; IBD: Inflammatory bowel disease; CAD: coronary artery disease; DM: diabetes mellitus; UC: Ulcerative colitis; CD: Crohn’s disease