Table 3.

Prediction Performance of NPS-HomPPI using Homologs from the Safe, Twilight, Dark Zones.

Binding Type	Homology Zone	Prediction Coverage	CCP	SensitivityP	SpecificityP	AccuracyP
	Safe	14% (5/36)	0.55	0.62	0.57	0.94
Enzyme-inhibitor, - Transient	Twilight	50% (18/36)	0.52	0.69	0.58	0.83
	Dark	19% (7/36)	0.12	0.23	0.20	0.83
	Total	83% (30/36)	0.44	0.58	0.50	0.85
	Safe	23% (7/30)	0.56	0.64	0.60	0.91
Non-enzyme-inhibitor, - Transient (NEIT)	Twilight	37% (11/30)	0.37	0.48	0.57	0.78
	Dark	33% (10/30)	0.36	0.37	0.50	0.86
	Total	93% (28/30)	0.42	0.48	0.55	0.84
	Safe	52% (14/27)	0.70	0.81	0.72	0.91
Hetero-dimer, - Obligate	Twilight	33% (9/27)	0.52	0.58	0.64	0.82
	Dark	15% (4/27)	0.44	0.66	0.47	0.80
	Total	96% (26/27)	0.60	0.71	0.66	0.86
	Safe	38% (33/87)	0.84	0.90	0.84	0.96
Homo-dimer, - Obligate	Twilight	31% (27/87)	0.67	0.74	0.71	0.91
	Dark	28% (24/87)	0.36	0.47	0.44	0.84
	Total	97% (84/87)	0.65	0.73	0.68	0.91