Table 2.
Association between MDM4 Polymorphisms and SCCHN Risk by Tumor Sites
| Genotypes | Controls a n =321 (%) | Overall SCCHN
|
Oropharynx
|
Non-Oropharynx
|
|||
|---|---|---|---|---|---|---|---|
| Cases n=371 (%) | OR (95% CI) b | Cases n = 186 (%) | OR (95% CI) b | Cases n = 185 (%) | OR (95% CI) b | ||
| rs10900598 | |||||||
| GGc | 93 (29.0) | 233 (62.8) | 1.0 | 67 (36.0) | 1.00 | 51 (27.6) | 1.00 |
| GT | 156 (48.6) | 126 (34.0) | 1.0 (0.7–1.4) | 83 (44.6) | 0.6 (0.4–1.0) | 96 (51.9) | 1.3 (0.8–2.0) |
| TT | 72 (22.4) | 12 (3.2) | 1.1 (0.5–2.6) | 36 (19.4) | 0.7 (0.4–1.2) | 38 (20.5) | 1.1 (0.7–2.0) |
| GT+TT | 228 (71.0) | 138 (37.2) | 1.0 (0.7–1.4) | 119 (64.0) | 0.7 (0.4–1.0) | 134 (72.4) | 1.2 (0.8–1.9) |
| rs1380576 | |||||||
| CC | 150 (45.8) | 170 (46.3) | 1.0 | 76 (40.9) | 1.0 | 94 (50.8) | 1.0 |
| CG | 135 (42.6) | 158 (42.1) | 0.9 (0.7–1.3) | 89 (47.8) | 1.1 (0.7–1.6) | 69 (37.3) | 0.8 (0.5–1.2) |
| GG | 36 (11.6 | 43 (11.6) | 1.0 (0.6–1.7) | 21 (11.3) | 1.0 (0.5–2.0) | 22 (11.9) | 0.9 (0.5–1.7) |
| CG+GGc | 171 (54.2) | 201 (54.7) | 1.0 (0.7–1.3) | 110 (59.1) | 1.1 (0.7–1.6) | 91 (49.2) | 0.8 (0.6–1.2) |
| rs11801299 | |||||||
| GG | 202 (62.9) | 118 (31.8) | 1.0 | 122 (65.6) | 1.0 | 111 (60.0) | 1.0 |
| AG | 109 (34.0) | 179 (48.2) | 0.9 (0.6–1.3) | 59 (31.7) | 1.0 (0.6–1.5) | 67 (36.2) | 1.1 (0.7–1.6) |
| AA | 10 (3.1) | 74 (20.0) | 0.9 (0.6–1.4) | 5 (2.7) | 1.5 (0.5–4.8) | 7 (3.1) | 1.0 (0.4–2.9) |
| AG+AAc | 119 (37.1) | 253 (68.2) | 0.9 (0.7–1.3) | 64 (34.4) | 1.0 (0.7–1.5) | 74 (40.0) | 1.1 (0.7–1.6) |
a
The observed genotype frequency among the control subjects was in agreement with the Hardy-Weinberg equilibrium (chi-square = 0.183, P = 0.669 for rs10900598, chi-square = 0.451, P = 0.502 for rs1380576, and chi-square = 1.06, P = 0.303 for rs11801299).
b
ORs were adjusted for age, sex, smoking status, and alcohol use age, sex, smoking, drinking, and HPV16 serostatus in a logistic regression model.
c
Assumed risk genotypes; the risk genotypes used for the calculation were MDM4 rs10900598 GG, rs1380576 CG+GG, and rs11801299AG+AA, genotypes.