Table 4.
Joint Effects of HPV16 Seropositivity and MDM4 Genotypes on Risk of SCCOP Stratified by Smoking Status
| HPV16 status | Genotypes | Never smokers | Ever smokers | Adjusted OR (95% CI) a | |||
|---|---|---|---|---|---|---|---|
| Controls (92) | Cases (63) | Controls (229) | Cases (123) | Never smokers | Ever smokers | ||
| rs10900598 | |||||||
| − | GT+TT(Ref.) | 61 | 19 | 134 | 45 | 1.0 | 1.0 |
| − | GG | 23 | 8 | 62 | 28 | 1.0 (0.4–2.7) | 1.5 (0.8–2.7) |
| + | GT+TT | 7 | 24 | 26 | 31 | 13.1 (4.6–37.3) | 3.6 (1.9–6.8) |
| + | GG | 1 | 12 | 7 | 19 | 43.0 (5.0–367.4) | 7.9 (3.1–20.4) |
|
| |||||||
| HPV16 status | Genotypes | Never smokers | Ever smokers | Adjusted OR (95% CI) a | |||
|
| |||||||
| Controls (92) | Cases (63) | Controls (229) | Cases (123) | Never smokers | Ever smokers | ||
|
| |||||||
| rs1380576 | |||||||
| − | CC (Ref.) | 38 | 13 | 95 | 35 | 1.0 | 1.0 |
| − | CG+GG | 46 | 14 | 101 | 38 | 0.8 (0.3–2.0) | 1.0 (0.6–1.8) |
| + | CC | 5 | 14 | 12 | 14 | 9.4 (2.7–33.2) | 3.2 (1.3–7.8) |
| + | CG+GG | 3 | 22 | 21 | 36 | 25.0 (6.0–104.6) | 4.4 (2.2–8.6) |
|
| |||||||
| HPV16 status | Genotypes | Never smokers | Ever smokers | Adjusted OR (95% CI) a | |||
|
| |||||||
| Controls (92) | Cases (63) | Controls (229) | Cases (123) | Never smokers | Ever smokers | ||
|
| |||||||
| rs11801299 | |||||||
| − | GG (Ref.) | 54 | 21 | 119 | 43 | 1.0 | 1.0 |
| − | AG+AA | 30 | 6 | 77 | 30 | 0.5 (0.2–1.5) | 1.2 (0.7–2.1) |
| + | GG | 5 | 22 | 24 | 36 | 13.6 (4.3–43.4) | 4.1 (2.2–7.8) |
| + | AG+AA | 3 | 14 | 9 | 14 | 14.6 (3.5–60.8) | 4.5 (1.7–11.3) |
a
ORs were adjusted for age, sex, and alcohol drinking.