Table 5.
Joint Effect of HPV16 Seropositivity and MDM4 Genotypes on Risk of SCCOP Stratified by Drinking Status
| HPV16 status | Genotypes | Never drinker | Ever drinkers | Adjusted OR (95% CI) a | |||
|---|---|---|---|---|---|---|---|
| Controls (93) | Cases (37) | Controls (228) | Cases (149) | Never drinkers | Ever drinkers | ||
| rs10900598 | |||||||
| − | GT+TT(Ref.) | 58 | 9 | 137 | 55 | 1.0 | 1.0 |
| − | GG | 26 | 8 | 59 | 28 | 2.1 (0.7–6.3) | 1.3 (0.7–2.3) |
| + | GT+TT | 7 | 14 | 26 | 41 | 15.6 (4.7–52.1) | 3.8 (2.1–6.8) |
| + | GG | 2 | 6 | 6 | 25 | 25.4 (4.0–162.5) | 9.9 (3.8–25.9) |
|
| |||||||
| HPV16 status | Genotypes | Never drinker | Ever drinkers | Adjusted OR (95% CI) a | |||
|
| |||||||
| Controls (93) | Cases (37) | Controls (228) | Cases (149) | Never drinkers | Ever drinkers | ||
|
| |||||||
| rs1380576 | |||||||
| − | CC (Ref.) | 44 | 6 | 89 | 42 | 1.0 | 1.0 |
| − | CG+GG | 40 | 11 | 107 | 41 | 2.0 (0.7–6.0) | 0.8 (0.5–1.3) |
| + | CC | 5 | 8 | 12 | 20 | 13.6 (3.1–58.9) | 3.0 (1.3–6.8) |
| + | CG+GG | 4 | 12 | 20 | 46 | 26.5 (6.0–116.3) | 4.5 (2.4–8.7) |
|
| |||||||
| HPV16 status | Genotypes | Never drinker | Ever drinkers | Adjusted OR (95% CI) a | |||
|
| |||||||
| Controls (93) | Cases (37) | Controls (228) | Cases (149) | Never drinkers | Ever drinkers | ||
| rs11801299 | |||||||
| − | GG (Ref.) | 47 | 14 | 126 | 50 | 1.0 | 1.0 |
| − | AG+AA | 37 | 3 | 70 | 33 | 0.3 (0.1–1.0) | 1.3 (0.8–2.3) |
| + | GG | 5 | 12 | 24 | 46 | 9.2 (2.7–32.1) | 4.9 (2.7–8.9) |
| + | AG+AA | 4 | 8 | 8 | 20 | 8.3 (2.0–34.6) | 5.4 (2.2–13.4) |
a
ORs were adjusted for age, sex, and smoking.